A Mechanism Misregulating p27 in Tumors Discovered in a Functional Genomic Screen
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چکیده
منابع مشابه
A Mechanism Misregulating p27 in Tumors Discovered in a Functional Genomic Screen
The cyclin-dependent kinase inhibitor p27(KIP1) is a tumor suppressor gene in mice, and loss of p27 protein is a negative prognostic indicator in human cancers. Unlike other tumor suppressors, the p27 gene is rarely mutated in tumors. Therefore misregulation of p27, rather than loss of the gene, is responsible for tumor-associated decreases in p27 protein levels. We performed a functional genom...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2007
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.0030219